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Our bodies create their own free radicals, adding to the external free radicals that also besiege our bodies

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation

R., Galyan, E

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This is a more elegant and, in many research models, a more effective approach than introducing a constant, unnatural elevation